SPECIFIC PATHOMORPHOLOGY OF LIVER TISSUE IN NEONATAL SEPSIS

under the influence of endogenous and/or exogenous infection of babies in the perinatal period, the response reaction of immune organs that have not yet developed during fetal development develops differently (in the form of immunodeficiency) and is manifested by dystrophic and necrotic changes of most parenchymatous organs[1]. Sepsis is most common in low- and middle-income countries. About 670,000 newborns die from sepsis each year[4]. In this study, the liver tissue of infected and diagnosed sepsis babies born before and after term was studied at autopsy. It is manifested by the development of toxic dystrophy (vacuolar dystrophy) and fatty dystrophies with small droplets in hepatocytes in the systemic response of acutely developed vessels. As is known, prematurity and low body weight are considered as the main risk factors for both the development of sepsis itself in newborns and its severity [2,3,5]. Today, although a high level of progress has been achieved in the effective treatment and comparative diagnosis of this disease, nevertheless, neonatal sepsis remains a leader among the current tasks in biological and medical sciences.