Published March 10, 2023
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Eco-Friendly One Pot Synthesis of Coumarin Derivatives by Pechmann Condensation using Tamarind Juice as a Biocatalyst
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Description
An efficient and eco-friendly synthetic method has been established for synthesis of 7-hydroxy-4-methyl coumarin and its derivatives using tamarind juice as a biocatalyst. The condensation reaction of Substituted phenol with ethyl acetoacetate (EAA) successfully carried out using tamarind juice as a green and efficient catalyst at 90°C in aqueous condition. This green biocatalyst has been utilised effectively for pechmann reaction with good yield of product, easy workup and eco-friendly reaction conditions.