ANTI-ANAEMIA AND HAEMOPOIETIC EVALUATION OF TRIGONELLA FOENUM GRAECUM IN RODENT MODEL

Anaemia also defined as a decreased quantity of circulating red blood cells (RBCs), otherwise known as erythrocytes, is a major source of morbidity and mortality worldwide. The medicinal plants are always the good source to overcome many diseases across the world as they have enormous potential in the form of phytochemical (Phytomedicines) which are used in the treatment of various diseases. Trigonella foenum-graecum found to have Analgesic, Anti -inflammatory, neuropharmacological and cytotoxic activity. Thus, this study deals with the anti anemic activity of Trigonella foenum-graecum in rodent model. The plant material was collected & subjected to hydroalcoholic extraction followed by phytochemical screening & in vivo testing for various parameters in rat. The result showed that was found to be 9.43 %. Phytochemical analysis revealed the presence of large chemical groups that are: alkaloids, flavonoids, polyphenols, sterols, terpenes, glycosides and saponins. An increased number of red blood cells were observed after treatment with the extract of Trigonella foenum-graecum. The results show that the rats of the groups G1,G3, G4 and G5 have almost completely recovered RBC level  & hemoglobin at the 13th day of study period (8.213± 0.410), (7.156± 0.944), (8.315±0.554) and (8.281±0.459) respectively. The rats of groups G3, G4, and G5 the increased of WBCs at day 13 was (8.2±0.548), (8.431±0.447), (8.638±0.572) respectively. From the results obtained it can be concluded that Trigonella foenum-graecum exhibit potential to heal anaemia.

Keywords: RBC, WBC, Haemoglobin, Trigonella foenum phytochemical , Medicinal plants