Systemic Treatment with Cigarette Smoke Extract Affects Zebrafish Visual Behaviour, Intraocular Vasculature Morphology and Outer Segment Phagocytosis

Gómez Sánchez, Alicia; Colucci, Patrizia; Moran, Ailis; Moya López, Alexandro; Colligris, Basilio; Álvarez, Yolanda; Kennedy, Breandán N.

doi:10.5281/zenodo.7653442

Published February 18, 2023 | Version v1

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Systemic Treatment with Cigarette Smoke Extract Affects Zebrafish Visual Behaviour, Intraocular Vasculature Morphology and Outer Segment Phagocytosis

1. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin D04 V1W8, Ireland.
2. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
3. Ocupharm Diagnostic Group Research, Faculty of Optic and Optometry, Universidad Complutense de Madrid, Madrid, Spain
4. UCD School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin D04 V1W8, Ireland.

Underlying dataset and analysis tests of the results described in the article "Systemic Treatment with Cigarette Smoke Extract Affects Zebrafish Visual Behaviour, Intraocular Vasculature Morphology and Outer Segment Phagocytosis".

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Name	Size
Fig. 1C-D-F. Cigarette Smoke Extract Impairs Visual Behaviour..xlsx md5:1366e394a51d13e98cbe3661f7959247	24.8 kB	Download
Fig. 1D Figure 1. Cigarette Smoke Extract Impairs Visual Behaviour..pzfx md5:c2b63b76cb04c2344a1bc8c506a2aae9	33.1 kB	Download
Fig. 1F Figure 1. Cigarette Smoke Extract Impairs Visual Behaviour..pzfx md5:3de7fbcb15e0df78c9529a176a94ac0b	26.7 kB	Download
Fig. 4B. Standard Optokinetic Response and Visual Motor Response are affected when CSE is applied for 24 hours..pzfx md5:2d0e8d937e533f3d9550ab1bfd95af58	17.2 kB	Download
Fig. 4C. Standard Optokinetic Response and Visual Motor Response are affected when CSE is applied for 24 hours..pzfx md5:67994eb28b3f81d413c8c2a3457773c1	3.5 MB	Download
Fig. 5. Shorter CSE treatment increases gpx1a expression.pzfx md5:7c0a71485ce3030f490345b4aeab6c28	92.9 kB	Download
Fig. 6. Hyaloid vessels are dilated with 48 hours Cigarette Smoke Extract Systemic Treatment..pzfx md5:0498e03683b2ab8d3608c5586fbb9b0f	47.9 kB	Download
Fig. 7. Axial Length, Lens and Ganglion Cell Layer appear increased with 48 hours Cigarette Smoke Extract Systemic Treatment..pzfx md5:581085cb31b39c3903c2bc0dd512d7fc	78.8 kB	Download
Fig. 8. Exposure to cigarette smoke extract causes increased levels of RPE phagosomes.pzfx md5:a1b1f52a8beb5a7b12c2e340c8a24f8e	16.5 kB	Download
Figure 2. Visual Acuity and Contrast Sensitivity are affected by Cigarette Smoke Extract Treatment..pzf md5:6eb4bd6f1db59264fd0143d2ed8c5579	2.4 MB	Download
Figure 3. Cigarette Smoke Extract decreases the ability to discriminate colour patterns..pzfx md5:4593506f418272057b6778b7184b0a2d	128.4 kB	Download

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European Commission
3D NEONET - Drug Discovery and Delivery NEtwork for ONcology and Eye Therapeutics 734907
European Commission
CRYSTAL3 - Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease 101007931

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Systemic Treatment with Cigarette Smoke Extract Affects Zebrafish Visual Behaviour, Intraocular Vasculature Morphology and Outer Segment Phagocytosis

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