DESIGN AND DEVELOPMENT OF GLIBENCLAMIDE LOADED MICROPARTICLES

Controlled release drug delivery systems are more preferred than the conventional drug delivery systems due to its enhanced bioavailablity and patient compliance. Glibenclamide is a sulfonylurea used in the management of diabetes mellitus.The aim of this study was the formulation and physicochemical characterization of Glibenclamide by using polymers like chitosan and Arachis oil at different concentrations. microparticles were prepared by Emulsification Crosslinking method by using chitosan as polymer and various concentrations of Trypolyphosphate (10-25mg/ml) in aqueous solution as cross linking agent. The polymeric systems obtained were characterized in terms of particle size and morphology,IR spectroscopy, entrapment efficiencyand drug loading, Swelling degree, the release of active substances from the chitosan matrix and the other micromeritic studies like Carr’s index, Hausner’s ratio, and angle of repose.It was observed from the invitro release studies, formulations F7and F8 showed sustained drug release for desired time of 12h and the drug release from microparticles follow non-Fickian diffusion mechanism.

Key words: Glibenclamide, Chitosan, Emulsification Crosslinking method, Tripolyphosphate