Published February 17, 2023
| Version v1
Journal article
Open
A rare case of Levofloxacin induced ventricular arrhythmia
Authors/Creators
- 1. Department of General Medicine, Shree Krishna Hospital and Pramukhswami Medical College, Karamsad, Gujarat - 388325
Description
ABSTRACT
Drug induced cardiac arrhythmias are seen commonly in clinical practice. Amongst drugs, antibiotics have a specific predisposition, and amongst them, macrolides and fluoroquinolones are specifically seen to have such a tendency. However, amongst fluoroquinolones, the rate of incidence of quinolone induced cardiac arrhythmia is reported as 5.4 cases per 10 million prescriptions.1 Here, we report a rare case of a probable Adverse Drug Reaction (ADR) i.e., Left Ventricular inferoposterior surface bigeminy recorded 24 hours after initiation of levofloxacin which disappeared after 24 hours of its discontinuation.
Files
6. CR Krushan.pdf
Additional details
References
- Abo‐Salem E, Fowler JC, Attari M, Cox CD, Perez‐Verdia A, Panikkath R, Nugent K. Antibiotic‐induced cardiac arrhythmias. Cardiovascular therapeutics. 2014 Feb;32(1):19-25.
- Falagas ME, Rafailidis PI, Rosmarakis ES. Arrhythmias associated with fluoroquinolone therapy. International journal of antimicrobial agents. 2007 Apr 1;29(4):374-9.
- Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF. Effects of three fluoroquinolones on QT analysis after standard treatment courses. Annals of noninvasive electrocardiology. 2006 Jan;11(1):52-6.
- Makaryus AN, Byrns K, Makaryus MN, Natarajan U, Singer C, Goldner B. Effect of ciprofloxacin and levofloxacin on the QT interval: is this a significant" clinical" event?. Southern medical journal. 2006 Jan 1;99(1):52-7.
- Noel GJ, Goodman DB, Chien S, Solanki B, Padmanabhan M, Natarajan J. Measuring the effects of supratherapeutic doses of levofloxacin on healthy volunteers using four methods of QT correction and periodic and continuous ECG recordings. The Journal of Clinical Pharmacology. 2004 May;44(5):464-73.
- Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R. Effects of three fluoroquinolones on QT interval in healthy adults after single doses. Clinical Pharmacology & Therapeutics. 2003 Apr;73(4):292-303.
- Rao GA, Mann JR, Shoaibi A, Bennett CL, Nahhas G, Sutton SS, Jacob S, Strayer SM. Azithromycin and levofloxacin use and increased risk of cardiac arrhythmia and death. Ann Fam Med. 2014 Mar-Apr;12(2):121-7. doi: 10.1370/afm.1601.
- Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ. A method for estimating the probability of adverse drug reactions. Clinical Pharmacology & Therapeutics. 1981 Aug;30(2):239-45.