CONCEPT AND EVALUATION OF ANTHELMINTIC ACTIVITY IN TERMINALIA CORIACEA LEAF EXTRACT

The purpose of this study was to investigate Anthelmintic activity of aqueous and Methanolic leaf extract of Terminalia Coriacea {Roxb} Wight & Arn based on traditional consumption approx 4 grams of Terminalia Coriacea (Leathery Murdah) leaves paste taken orally for the treatment of Diarrhea, Anti-nociceptive effect, Wound healing, Antipyretic activity. Traditionally used medicine in many parts of India especially in rural areas due to availability and low cost from natural form. Anthelmintic activity was assessed with two different solvents extracts at five different concentrations with recording the time of  paralysis and time of death were Albendazole as a reference standard drug to see the potential of the extract. The lowest time for paralysis and death of worms for the test sample at highest concentration (100mg/ml) of the Aqueous Leaf Extract of Terminalia Coriacea paralysis time was 6min 3 seconds and death time 15min 1 sec and Methanolic Leaf Extract of Terminalia Coriacea paralysis time was 5min 2 seconds and death time 12min 3seconds which gradually decreased with the increase in the concentration which  significantly result as Doses Dependent increase.Therefore, further studies are suggested to evaluate the possible mechanism of action and the active compounds responsible for the biological activities of the plant extract.

Keywords: Terminalia Coriacea, Aqueous Leaf extract, Methanolic Leaf Extract, Anthelmintic Activity, Albendazole