Published September 9, 2021 | Version v1
Journal article Open

Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent

Authors/Creators

  • 1. Department of Chemistry, Scripps Research, United States
  • 2. Automated Synthesis Facility, Scripps Research
  • 3. Chemical Process Development, Bristol Myers Squibb

Description

An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the Ψ-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to obtain.

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acs.orglett.1c02736.pdf

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