PAGER: constructing PAGs and new PAG–PAG relationships for network biology

Pathway and Annotated-list Gene-signature Electronic Repository (PAGER) is an online systems biology tool for constructing and visualizing gene and PAG networks from multiple PAG genesets.

PAG stands for Pathway, Annotated-list and Gene-signature. A PAG geneset represents a set of genes that share a common feature, whether they belong within the same pathway, share common biological processes, are co-differentially expressed under a particular condition of an experiment or clinical sample, or share a common downstream target or function.

Available at: http://discovery.informatics.uab.edu/PAGER

Acknowledgements:

• Zongliang Yue, Qi Zheng, Michael T Neylon, Minjae Yoo, Jimin Shin, Zhiying Zhao, Aik Choon Tan, Jake Y Chen, PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology, Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D668–D676,https://doi.org/10.1093/nar/gkx1040

File description

The GMT file format is a tab delimited file format that describes gene sets. In the GMT format, each row represents a PAG. The first column is PAG identifier, the second column is PAG link and the third and left columns are PAG genes.