Published February 7, 2023 | Version v1.0
Journal article Open

Discovery and characterization of a chemical probe targeting the zinc-finger ubiquitin-binding domain of HDAC6

Authors/Creators

  • 1. University of Toronto

Description

These data are the R scripts, environments, output used for analyzing chemoproteomics data.

The volcano plot shown in the manuscript is based on the DEP R package.

To validate the enrichment output from DEP, the proteomics data was also processed with the proDA package.

Filename (7 files) Description
combined_protein_Int.txt Output from database search
hdac6_dep_submitted.R script used to process data (from DEP package)
hdac6_dep_submitted.R.RData workspace environment from DEP package
hdac6probecontrol_dep.csv exported list of p-value and fold-change from DEP
hdac6probecontrol_proda.csv exported list of p-value and fold-change from proDA
hdac6proda_submitted.R proDA script
hdac6proda_submitted.RData proDA workspace environment

Notes

PXD039880 - the raw data is also uploaded to PRIDE.

Files

combined_protein_Int.txt

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