Published February 6, 2023
| Version v1
Journal article
Open
Alphafold prediction of the Plasmodium TRAP I domain for mutants design.
Authors/Creators
- 1. Heidelberg University Medical School
- 2. Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School
Description
Plasmodium sporozoites have several surface proteins, including the single-pass transmembrane adhesin thrombospondin related anonymous protein (TRAP). TRAP harbors two extracellular domains, the I-domain and the thrombospondin type I repeat, TSR. TRAP I domain in the “closed” conformation is unbound and has low adhesion and no signaling activity. We use Alphafold to predict the Plasmodium TRAP I domain for mutants design. Here is the Alphafold predicted structures of the TRAP I domain.