SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome
Authors/Creators
- 1. Department of Biomedical Sciences for Health, Università degli Studi di Milano, 20133 Milan, Italy.
- 2. R&D Department, Mindray Bio-Medical Electronics Co., Ltd., Shenzhen 518057, China.
- 3. Department of Cardiovascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, 20097 Milan, Italy.
- 4. O.U. of Clinical Pathology, Department of Pathology and Laboratory Medicine, IRCCS Policlinico San Donato, 20097 Milan, Italy.
Description
Galliera E, Massaccesi L, Yu L, He J, Ranucci M, Corsi Romanelli MM. SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome. Biomolecules. 2022 Jun 13;12(6):826. doi: 10.3390/biom12060826. PMID: 35740951; PMCID: PMC9220996.
Abstract
Since no definitive cure for COVID-19 is available so far, one of the challenges against the disease is understanding the clinical features and the laboratory inflammatory markers that can differentiate among different severity grades of the disease. The aim of the present study is a comprehensive and longitudinal evaluation of SCD14-ST and other new inflammatory markers, as well as cytokine storm molecules and current inflammatory parameters, in order to define a panel of biomarkers that could be useful for a better prognostic prediction of COVID-19 mortality. SCD14-ST, as well as the inflammatory markers IL-6, IL-10, SuPAR and sRAGE, were measured in plasma-EDTA of ICU COVID-19 positive patients. In this longitudinal study, SCD14-ST resulted significantly higher in patients who eventually died compared to those who were discharged from the ICU. The results suggest that the new infection biomarker SCD14-ST, in addition to new generation inflammatory biomarkers, such as SuPAR, sRAGE and the cytokines IL-6 and IL-10, can be a useful prognostic tool associated with canonical inflammatory parameters, such as CRP, to predict SARS-CoV-2 outcome in ICU patients.
Files
Restricted
The record is publicly accessible, but files are restricted. Log in to check if you have access.
Request access
If you would like to request access to these files, please fill out the form below.
You need to satisfy these conditions in order for this request to be accepted:
These data are available upon duly motivated request to the corresponding author of the article
You are currently not logged in. Do you have an account? Log in here