PROTECTIVE EFFECT OF CROSSANDRA UNDULAEFOLIA ON PARACETAMOL INDUCED HEPATOTOXICITY IN ALBINO RAT

Many hepatoprotective herbal preparations have been recommended in
alternative system of medicine for the treatment of hepatic disorders. No
systemic study has been done on protective efficacy of Crossandra
Undulaefolia belonging to family Acanthanceae to treat diseases. The
Hydro-Ethanolic extracts of aerial parts of Crossandra Undulaefolias
(ECU). The animals were weighed each and divided in group of five.
Liver damage was achieved by injecting Paracetamol (2 g/kg). The
treatment groups pretreated with ECU Group-IV (200mg/kg) and Group-
V (400mg/kg). Silymar in was used as reference standard drug. At the
end of 7 days, blood was collected, liver extracted, weighed,
processed for histopathological assessments and alteration in the levels of
biochemical markers of hepatic damage like serum transaminases
(AST,ALT), alkaline phosphatase (ALP) , bilirubin cholesterol, high
density lipoprotein (HDL) and tissue GSH were tested in all the groups.
The ECU exhibited a significant hepatoprotective effect by lowering the
elevated serum levels of AST, ALT, ALP, total and direct serum
bilirubin, cholesterol and significantly (p<0.05) increased HDL and
moderately increased total protein and albumin in a dose dependent
manner These biochemical observations were supplemented by treatment
of liver toxicity in traditional medicine. Histopathological examination
of liver sections. These findings suggest the use of this plant for its
Hepatoprotective effects.