Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis

We conducted the first large-scale epigenome-wide meta-analysis of blood DNA methylation and recent use of opioid medications. There were five participating studies (10,842 individuals; 9,886 European ancestry and 956 African ancestry participants) including four that used the newer Illumina EPIC/850K array and one that used the older Illumina 450K array. We identified novel loci differentially methylated in relation to opioid medication use.