Dataset related to the article "Cardiac magneticresonanceforprophylactic implantable-cardioverter defibrillator therapy international study:prognosticvalueofcardiac magnetic resonance-derivedrightventricular parameters substudy"

This record contains partial raw data related to the article “Cardiac magneticresonanceforprophylactic implantable-cardioverter defibrillator therapy international study:prognosticvalueofcardiac magnetic resonance-derivedrightventricular parameters substudy"

Aims: Right ventricular (RV) systolic dysfunction (RVSD) has been recognized as an important determinant of outcomes in heart failure (HF) patients. However, assessment of RV volumes is challenging as the geometric complexity of the RV prohibits quantitative assessment by traditional 2D-echocardiography. Cardiac magnetic resonance (CMR) is the gold standard for RV chamber quantification with its high spatial resolution, precise definition of anatomy, and excellent reproducibility. In this study, we sought to investigate the incremental prognostic value of CMR-derived RV volumetric parameters in a large cohort of HF patients with reduced ejection fraction (HFrEF).

Methods and Results: Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography
(n=2449). RVSD was defined as RV ejection fraction (RVEF) <45%. Kaplan–Meier curves and cox regression were used to  investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8±14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0±10.8. Median follow-up was 959 days (interquartile range: 560–1590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio=1.44; 95%CI[1.09–1.91]; P=0.01). On subgroup analyses,the prognostic value of RVSD was more pronounced in NYHA I/II than in NYHAIII/IV, in LVEF <35% than in LVEF ≥35%, and in patients with renal dysfunction when compared to those with normal renal function.

Conclusions: RV dysfunction is an independent predictor of all-cause mortality in a large cohort of patients with HFrEF, with the prognostic value of RV dysfunction being more pronounced in select subgroups; likely reflecting the importance of RV function in the early stages of HF progression.