Dataset related to article "Effect of chemotherapy on tumour-vessel relationship in colorectal liver metastases"
Authors/Creators
- 1. IRCCS Humanitas Research Hospital, via Manzoni 56,20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele – Milan, Italy
- 2. IRCCS Humanitas Research Hospital, via Manzoni 56, 20072 Rozzano (Mi) - Italy
Description
This record contains raw data related to article “Effect of chemotherapy on tumour-vessel relationship in colorectal liver metastases"
Abstract
Chemotherapy is the fundamental companion of surgery for treatment of patients with colorectal liver metastases (CLMs)1 .
When chemotherapy leads to tumour shrinkage, this is expected to have two major effects. It reduces tumour burden and, most relevant for surgeons, shrinkage may detach CLMs from vessels, enabling more conservative procedures and increasing resectabil- ity. Although the first effect is indisputable, the second one has not been confirmed completely by data. In two studies 6,7 with some limitations, including small sample size and low adoption of targeted therapies, tumour shrinkage led to regression of tumour–vessel contact in only one-fifth of patients. The authors’ group has pursued an aggressive ultrasound- guided parenchyma-sparing approach based on a vessel-sparing policy, scheduling tumour detachment from vessels or partial
vein resection/reconstruction whenever possible since 2004. This has allowed accurate analysis of modification of the tumour–vessel relationship after chemotherapy. The aim of this study was to elucidate whether tumour shrinkage by chemother- apy corresponds to regression of CLM–vessel contact
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Additional details
Related works
- Is supplement to
- Journal article: 35165692 (PMID)
- Journal article: 10.1093/bjs/znac010 (DOI)