CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis
Description
Data folder contains preprocessed CyTOF files (FCS format) from a 31-marker mass cytometry panel to examine all major PBMC lineages and specifically CD4 and CD8 T cell memory dynamics in people with HIV (PWH) who are durably ART suppressed for an average of 6.7 years (LT-ART, n = 10) and PWH in the first 500 days following ART initiation (A5248, n = 10). The panel also includes markers of activation (HLA-DR, CD38, CCR5), activation/exhaustion (PD-1), proliferation (Ki67), survival (Bcl-2) and long-lived memory (CD127).
Preprocessed data objects (A5248_subsample.h5ad, LT-ART_subsample.h5ad) for unsupervised analysis can be accessed using the 'read_h5ad' function in Scanpy.
All source code for reproduction of the results can be found in the GitHub repository: https://github.com/glab-hiv/immune-recovery
Files
data.zip
Files
(6.0 GB)
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md5:f60a63615ba47d89e3a3a444cdb91397
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