Hematology and Biochemical Indicators at Pregnant Women with Enterovirus Infections

For the purpose of revealing of clinic-laboratory criteria of early diagnostics of placentary insufficiency the hematology and biochemical indicators in dynamics of pregnancy in group of women with enterovirus infections were studied. It was established, that at the complicated pregnancy from 8-12 weeks there was a hemoconcentration with increase in level of hemoglobin. Studying of system of a hemeostasis at the complicated pregnancy has revealed number of the decrease in trombosytes from 283,7×109 /l during 8-12 weeks to 239,9×109 /l during 35-39 weeks; the concentration increase in fibrinogen by 36,1% at the end of pregnancy in comparison with I trimester; shortening of activated plasma recalcification time during childbirth by 26%; the increase in trombosytes aggregation by 19% at the end of pregnancy. Changes of indicators of homeostasis system underline its value for normal fetoplasentar formation depending on a complex and restriction of blood loss during childbirth. In group of women with enterovirus infections, there were changes of a hemostasis in a direction of aggravation of anticoagulation factors deficiency and the risk of a blood clot formation increase. The obtained data about character of changes in system the lipid peroxide oxidation at pregnancy in group of women with enterovirus infection, testify that at placentary insufficiency activity of processes of the lipid peroxide oxidation posses phase character and differs on intensity depending on severity level of hypotrophy. The most essential deviations from normal state were established during enterovirus infection. Activation of the lipid peroxide oxidation was accompanied by low level of αtocopherol and general blood antioxidant activity that specified in decrease in buffer capacity of antioxidant protection. The greatest pressure in the antioxidant protection system was observed during pregnancy at patients with enterovirus infection. During infection level of antioxidant activity was initially high (12,0+0,98 st.units) and was not compensated by some increase in α-tocopherol (10,2+1,12 mmol/l) during 8-15 week of pregnancy. It specifies in approach of pregnancy during exhaustion of antioxidant protection system.