Published June 8, 2023
| Version v1
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Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment
Authors/Creators
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Perez-Garcia, Javier1
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Espuela-Ortiz, Antonio1
- Hernández-Pérez, José María2
- González-Pérez, Ruperto3
- Poza-Guedes, Paloma3
- Martin-Gonzalez, Elena1
- Eng, Celeste4
- Sardón-Prado, Olaia5
- Mederos-Luis, Elena6
- Corcuera-Elosegui, Paula5
- Sánchez-Machín, Inmaculada6
- Korta-Murua, Javier5
- Villar, Jesús7
- Burchard, Esteban G.4
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Lorenzo-Diaz, Fabian1
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Pino-Yanes, Maria1
- 1. Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain.
- 2. Pulmonary Medicine Service, Hospital Universitario de N.S de Candelaria, La Laguna, Tenerife, Spain.
- 3. Severe Asthma Unit, Allergy Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
- 4. Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA.
- 5. Division of Pediatric Respiratory Medicine, Hospital Universitario Donostia, San Sebastián, Spain.
- 6. Allergy Department, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
- 7. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Description
Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021.
This Supplement Data contains the following items:
| Additional Table 1 | List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Europeans (discovery). |
| Additional Table 2 | List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from pharyngeal samples in Europeans (discovery). |
| Additional Table 3 | List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from nasal samples in Europeans (discovery). |
| Additional Table 4 | Summary results of enrichment analyses using the Enrichr platform. |
| Additional Table 5 | Summary results of stratified enrichment analyses by biological sample type. |
| Additional Table 6 | List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in African Americans (replication phase). |
| Additional Table 7 | List of independent mbQTLs associated with p<1x10-5 in the mbGWAS from saliva samples in Latinos (replication phase). |
| Additional Table 8 | Summary results of replication enrichment analyses in saliva samples. |
| Additional Table 9 | Summary statistics of the mbQTL analysis of Streptococcus in nasal samples. |
| Additional Table 10 | Summary statistics of the mbQTL analysis of Campylobacter in pharyngeal samples. |
| Additional Table 11 | Summary statistics of the mbQTL analysis of Tannerella in pharyngeal samples. |
| Additional Table 12 | Summary table of the different genetic models tested for each mbQTL pair. |
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Additional details
Related works
- Is part of
- Journal article: 10.1016/j.jaci.2023.05.021 (DOI)
References
- Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment [published online ahead of print, 2023 Jun 8]. J Allergy Clin Immunol. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021