Published December 2, 2022
| Version v1
Journal article
Open
Large Protein Assemblies for High-Relaxivity Contrast Agents: The Case of Gadolinium-Labeled Asparaginase
Creators
- 1. University of Florence and CIRMMP
- 2. University of Florence
Description
A gadolinium(III)-DOTA derivative has been conjugated to asparaginase, and its relaxation properties have been investigated to assess its efficiency as a possible theranostic agent. The field-dependent 1H longitudinal relaxation measurements of water solutions of gadolinium(III)-labeled asparaginase indicate a very large increase in the relaxivity of this paramagnetic protein complex with respect to small gadolinium chelates, opening up the possibility of its use as an MRI contrast agent.
Files
Files
(13.8 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:703ccca43dcb2773bdd09dd66e7225a3
|
13.8 kB | Download |