Reproduction Of Adequate Model Of Chronic Renal Failure

The main purpose of the work was to create an adequate model of chronic renal failure, considering the etiological factor of the disease. For this purpose, 32 chinchilla rabbits weighing 4 to 6 kg were divided into three groups. One of the branches of the renal artery was tied up in 10 rabbits of the 1st group. A highly toxic exudate, received from patients operated on for peritonitis, was introduced to the renal parenchyma of 10 rabbits in the 2-nd group of animals. One of branches of the renal artery was tied up, with the introduction of the highly toxic exudate to the renal parenchyma of the animals of the 3rd group (12 rabbits). Pathological process observed within 1 month. Based on the content of creatinine, urea and residual nitrogen in blood we came to the conclusion that creation of ischemia of the parenchyma with further introduction of pathogenic microflora and toxic substances allows to reproduce the adequate model of chronic renal failure.