Published November 15, 2021
| Version v1
Dataset
Open
Murine brain organoids developmental profiling
Authors/Creators
- 1. University of Verona
Description
The dataset includes the RNA sequencing data generated for the study entitled "Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity" by Ciarpella et al. Starting from mouse neuronal stem cells, we generate organoids to recapitulate the hippocampal structure as new platform for modeling diseases, for drug screening and for organ transplantation in regenerative medicine. Performing RNA sequencing in organoids at different stage of proliferation and maturation, we obtained a measure of the cellular diversity within the organoids, the degree of differentiation and the affinity to hippocampus or cortex tissue (reference samples).
Notes
Project also funded by Fondazione Telethon–Italy (Grant Number GSP20004_PAsMCT8006); Italian patient association la Colonna and GALM and University of Verona (Grant Number DDSP-FUR-6616); University of Milan (Grant Number BIOMETRA15-6-3003005-1 and PSR2018_RIVA_BIFARI); Fondazione Telethon–Italy (Grant Number GGP19250)
Files
HERMES_meta_RNAseq.pdf
Files
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Additional details
Related works
- Is new version of
- Dataset: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA778927 (URL)
- Is published in
- Journal article: 10.1016/j.isci.2021.103438 (DOI)