The Role of the Antioxidant Defence System in Pathogenetic changes of Protein Metabolism caused by Long-term Liver Ischemia

Under conditions of chronic intoxication in white rats alterations in pathogenesis of protein exchange have been observed in blood depending on the hepatic ischemia period and the role of the antioxidative protective system of the organism has been elucidated . The experiment has been performed on 45 white rats, divided into 3 groups. The 1st group (5)- intact animals, the 2nd group (20 animals)- 30-minute ischemia, the 3rd group (20 animals)-under conditions of 30-minute ischemia the antioxidative protective system model was created. Total protein, albumin , α1-, α2-, β-, γ-globulin concentrations and LDH activity were compared with the intact condition in the 2nd group and with the intact condition and 30-minute ischemia in the 3rd group.