ENDOTHELIAL DYSFUNCTION AND CYTOKINES: A ROLE IN THE DEVELOPMENT OF PREMATURE DEPARTMENT OF A NORMALLY LOCATED PLACENTA

For the normal development and functioning of the placenta, it is important to have a balance between various mechanisms of angiogenesis, as well as a balance between the processes of angiogenesis and apoptosis, which is maintained by the ratio of proangiogenic and antiangiogenic factors secreted by both the endothelial cells themselves and the cells of the microenvironment. Changes in the balance of cytokines and vascular growth factors in the microenvironment of endothelial cells underlie pathological disorders of placentation, gestation at different stages of pregnancy, and preterm birth.