Published December 9, 2022
| Version v1
Journal article
Open
ELEVATED HOMOCYSTEINE LEVELS IN THE DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION IN PREECLAMPSIA
Authors/Creators
- 1. Doctor of Medical Sciences Professor Tashkent State Dental Institute Tashkent Medical Academy Tashkent, Uzbekistan
- 2. Tashkent State Dental Institute Tashkent Medical Academy Tashkent, Uzbekistan
Description
In patients with preeclampsia, serum levels of homocysteine, fibrinogen, cholesterol, and C-reactive protein increase significantly, causing endothelial dysfunction. The severity of endothelial dysfunction coincides with the level of proteinuria and arterial hypertension. Long-term high levels of homocysteine in the serum of pregnant women with PE is one of the possible mechanisms for the development of placental disorders, hypoxia and fetal hypotrophy.