Published December 8, 2022
| Version v1
Journal article
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Cryo-electron Tomography: An Overview
Authors/Creators
- 1. 1*Department of Veterinary Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Navsari, Gujarat, India 2Department of Veterinary Microbiology, College of Veterinary Science and Animal Husbandry, Kamdhenu University, Navsari, Gujarat, India
Description
Viruses are macromolecular machineries which hijack cellular metabolism for replication. Viruses that are enveloped, comprise a large variety of DNA and RNA virus, many of which are notorious human or animal pathogen. Despite their importance, presence of lipid bilayers in their assembly had made most enveloped viruses too pleomorphic to be reconstructed as whole, by traditional structural biological methods. Structural biology of the virus lifecycle was hindered by sample thickness. Here is the report of the recent advances in the applications of cryo-electron tomography (cryo-ET) on enveloped viral structures and intracellular virus activities.