Published May 9, 2023
| Version v1
Dataset
Open
[Data S2] Microbiota dictate T cell clonal selection to augment graft-vs-host disease after stem cell transplantation
Authors/Creators
-
Yeh, Albert C.
- Koyama, Motoko
- Waltner, Olivia
- Minnie, Simone A.
- Boiko, Julie R.
- Shabaneh, Tamer
- Takahashi, Shuichiro
- Ensbey, Kathleen S.
- Schmidt, Christine R.
- Legg, Samuel R.W.
- Sekiguchi, Tomoko
- Nelson, Ethan
- Stevens, Andrew R.
- Bhise, Shruti S.
- Goodpaster, Tracy
- Chakka, Saranya
- Furlan, Scott N.
- Markey, Kate A.
- Bleakley, Marie E.
- Elson, Charles O.
- Bradley, Philip H.
- Hill, Geoffrey R.
Description
Data S2. GLIPH2 hits for all recipient pairs amongst B6 to B6D2F1 transplants with or without antibiotic exposure and 900cGy vs. 1300cGy TBI conditioning. For all TCRs within each recipient pair (12 mice total, 66 pairs for spleen; 15 pairs for SILP analysis), GLIPH2 specificity groups are generated as described in methods.
Notes
This file contains GLIPH2 output files referred to as Data S2. Grouping of lymphocyte interactions by paratope hotspots (GLIPH2) was performed as described in Huang et al (14) using the publicly available web portal (http://50.255.35.37:8080/, last accessed 8/16/2022, reference file mouse v1.0). We focused on specificity groups that contained at least 3 unique TCRs and exhibited significant V-gene bias (P < 0.05), cutoffs suggested in the original manuscript.
Files
GLIPH2 Results - 1906T G10_11.csv
Files
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