Study of changes in basic biochemical indicators of blood in the dynamics of development of modified alloxan diabetes in rats

The article presents data on biochemical changes in the blood of experimental rats on the background of modified alloxan diabetes in dynamics. At the same time, there is a violation of the balance between the prooxidant system and the antioxidant defense system in the body, which is accompanied by insulin deficiency in varying degrees of severity. The arising oxidative stress in diabetes is a vicious cycle in connection with an increase in the sources of free radical formation, a weakening of the activity of the antioxidant system, which leads to tissue damage. Oxidative stress is accompanied by a decrease in the absorption and consumption of glucose by adipose tissue, impaired insulin secretion by β-cells, an increase in the rate of lipid peroxidation, which results in metabolic syndrome.