AlphaFold2 models of human DNA polymerase epsilon catalytic subunit A

Models of the structure of human DNA polymerase epsilon catalytic subunit A built with the program AlphaFold2. Files are in mmCIF format.  Models include:

1) DPOE1_HUMAN_AF2_NterminalLobe_4m8o.cif : AlphaFold2 model built with template PDB:4M8O (yeast DNA polymerase epsilon N-terminal lobe with bound DNA)

2) DPOE1_HUMAN_AF2_FullLength_6wjv.cif : AlphaFold2 model built with template PDB:6WJV (yeast DNA polymerase epsilon full-length protein, N and C terminal lobes, without DNA).

3) DPOE1_HUMAN_AF2_NterminalLobe_4m8o_withDNA.cif : AlphaFold2 model built with template 4M8O (File #1 above) with DNA added from PDB entry 4M8O and subjected to energy minimization with the program AMBER using force field ff14SB.

The models were used to estimate the change in free energy of mutations found in patients with ovarian cancer, colon cancer, and endometrial cancer. Paper to be submitted Dec 2022.