FORMULATION AND EVALUATION OF FLOATING TABLET OF ALFUZOSIN HCL

The present work was to prepare and optimized floating tablet of Alfuzosin HCl. Alfuzosin HCl is an alfa-1 adrenergic receptor blocker for the treatment of benign prostatic hyper pleasia & hypertension which are design to increase the gastric residence time, thus prolonging the drug release. Alfuzosin HCL has the short biological half -life (3-5hrs) the dose may range from 2.5mg thrice a day to maximum of 10mg once a day which results into inconveniency to the patients. By preparing the floating tablets of Alfuzosin HCl that deliver the drug for longer time, reduced dosage frequency & better patient compliance. The tablets were prepared by direct compression method by using different polymers like HPMC K4M, carbapol 934, xanthum gum, guar gum, sodium bicarbonate & citric acid as gas generating agent with magnesium stearate, micro crystalline cellulose & talc as lubricants and glidant respectively. All the batches were evaluated for pre compression & post compression parameters and results were in the limits. All the batches exhibited appropriate floating lag time with in prescribed limits (<r3 minutes). Formulation F14 was selected as an optimum formulation as it shows 98.8 % drug elease at the end of 12 hours. Dissolution data were fitted to various models to acertain kinetic drug release.

Key words: Alfuzosin HCl ,HPMCK4M, xanthum gum, guar gum, carbapol 934 , sodium bicarbonate citric acid, magnesium sterate, micro crystalline cellulose& talc