FORMULATION AND EVALUATION OF FLOATING PULSATILE DRUG DELIVERY SYSTEM OF METOPROLOL TARTRATE

Oral route is one of the most popular, preferable and convenient route for drug administration. It possesses certain advantages like ease of administration, self-medication, patient compliance and flexibility with a wide range of dosage form The present study was aimed to develop a floating pulsatile formulation comprising an active Beta blocker Metoprolol tartrate with pulsatile release.  Floating behavior of tablet depends on added fillers in buoyant layer. Tablets containing lactose and 50% HPMCK100M floated earlier than tablets prepared with the lesser or higher concentrations of HPMCK100M. In addition, lactose has a higher water solubility, resultingin faster water uptake of medium into tablet. N2 formulation was used for further investigation. Only FPRT tablets of optimized batch (F3P9N2) were evaluated for in vitro drug release profile which was found to be 98.15% in 12hr. Stability studies on final formulation demonstrated its better stability profile at 4.0^OC and 25^OC however it was found a little unstable at higher temperature and humidity conditions.

Key words: Metoprolol tartrate, Floating behavior, Formulation, Evaluation