Published September 22, 2022
| Version v2
Dataset
Open
Integrative genetic analyses illuminates ALS heritability and identifies novel risk genes
Creators
- Megat Salim1
- Mora Natalia2
- Sanogo Jason1
- Roman Olga1
- Catanese Alberto3
- Alami Najwa Ouali3
- Freischmidt Axel3
- Xhuljana Mingaj4
- Hortense De Calbiac4
- Muratet Francois5
- Dirrig-Grosch Sylivie1
- Dieterle Stephane1
- Van Bakel Nick2
- Muller Kathrin3
- Sieverding Kirsten3
- Weishaupt Jochen6
- Munch Andersen Peter7
- Weber Markus8
- Neuwirth Christoph8
- Margelisch Markus8
- Sommacal Andreas8
- Van Eijk Kristel9
- Veldink Jan10
- Lautrettre Geraldine11
- Couratier Phillipe11
- Camuzat Agnes5
- Le Ber Isabelle12
- Grassano Maurizio13
- Chio Adriano13
- Boeckers Tobias3
- Ludolph Albert C3
- Roselli Francesco3
- Yilmazer-Hanke3
- Millechamps Stephanie5
- Kabashi Edor4
- Storkebaum Erik2
- Sellier Chantal1
- Dupuis Luc1
- 1. U1118 INSERM
- 2. Radboud University
- 3. Ulm University
- 4. UMR 1163 INSERM
- 5. Sorbonne University
- 6. University of Medicine Manheim
- 7. Umea University
- 8. Institute for Pathology, St Gallen
- 9. Utrecht of University
- 10. Utrecht University
- 11. CHU Limoges
- 12. Paris Brain Institute ICM
- 13. University of Turin
Description
Amyotrophic lateral sclerosis (ALS), the major adult onset motor neuron disease, has substantial heritability, in part shared with fronto-temporal dementia (FTD). We show here that ALS heritability is enriched in splicing variants and in binding sites of 6 RNA binding proteins including TDP-43 and FUS. A discovery and replication transcriptome wide association study (TWAS) identified 6 loci associated with ALS, 3 in known ALS loci (C9ORF72, SCFD1, SLC9A8) and 3 novel loci including NUP50 encoding for the nucleopore basket protein NUP50 In our meta-analysis of TWAS cohorts, NUP50 common variant was associated with ALS and to decreased expression of NUP50 in the central nervous system. Independently, we further show association of rare variants in NUP50 with ALS risk (P = 3.71.10-03; odds ratio = 3.29; 95%CI, 1.37 to 7.87) in a cohort of 9,390 ALS/FTD patients and 4,594 controls. Cells from one patient carrying a NUP50 frameshift mutation displayed a decreased levels of NUP50. Loss of NUP50 leads to neuronal death in cultured neurons, and motor defects in Drosophila and zebrafish models. Thus, our study identifies alterations in splicing in neurons as a critical pathogenic process in ALS, uncovers several new loci potentially contributing to ALS, and provides genetic evidence linking nuclear pore defects to ALS.
Files
ALSdiscoveryLMM.txt
Files
(2.4 GB)
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md5:54700c60c9c23d495a378094539378b2
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2.0 kB | Download |
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md5:24bb44dad602d375c30d2a315a3048c9
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22.8 MB | Download |
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md5:ee1629140e316532102369fd85b7236a
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817.9 kB | Download |
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md5:7dd3d2da9b0fd40cb8ae9799961e2841
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19 Bytes | Download |
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md5:782279dcea2860854217cef60b4b95cb
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19 Bytes | Download |
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md5:6f6a80cd1eecc5e8effc7327ae132b2e
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2.0 kB | Download |
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md5:9ec24c24e302a1ecf637e2b8d3d57910
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23.6 MB | Download |
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md5:92b883fc692686b0e55b8ed366c4be81
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732.3 kB | Download |
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md5:2b66a5e2d23ba55a8b4cc998f28f0ef0
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14 Bytes | Download |
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md5:d5cd16040711698158eac5531fdc2475
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19 Bytes | Download |
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md5:c319278c92a287ab8da33170f4272af9
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2.1 kB | Download |
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md5:2b8cbbe5f6943d84f2f3c38f4964c1bf
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20.4 MB | Download |
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md5:fa1431fc1ae1217f03a6b61fd62e25bb
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734.8 kB | Download |
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md5:19b145a80fca2bfc05f9a897de883910
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19 Bytes | Download |
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md5:49842a74bb8c2908fbc20b4932dfb273
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14 Bytes | Download |
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md5:63ab47e7ab9e2c3a919b36dd3765f1f0
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2.0 kB | Download |
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md5:5236e8bb9e49d3c5e3c85829c0374eaa
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21.4 MB | Download |
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md5:65d7c9a3701724b4e3ced31808ec32a9
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731.4 kB | Download |
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md5:3e4fa1527ba1751b1601bb30a77e5c8d
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19 Bytes | Download |
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md5:733f82285e097cb644858f3a121cd5f7
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19 Bytes | Download |
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md5:11503a6e294a8b47fd871a78fedc759c
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2.0 kB | Download |
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md5:685d1bb41af2ce3daf6d439f6a93ffe0
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19.0 MB | Download |
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md5:b0b6db93d2ea9feec32c6dfcaca74d39
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649.1 kB | Download |
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md5:b60eec17c13600418d08006cac2586df
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13 Bytes | Download |
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md5:48d0f66b8eab33b04b7fa8f992771802
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19 Bytes | Download |
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md5:7273cf7cfb7eae83907fd60b2d6bd8c1
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2.0 kB | Download |
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md5:6c181cff51089391a96c77a52082f115
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17.7 MB | Download |
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md5:cf2fbba23d5f9eeea363788308ac8c6f
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631.8 kB | Download |
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md5:869423b3166028699ef678539bebe4bc
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19 Bytes | Download |
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md5:a5122b19dab4e049c288bc97112ccdf1
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18 Bytes | Download |
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md5:f79fb1d357c5eab91f87acbe7c364df5
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2.0 kB | Download |
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md5:92155f6b34953621768ba90c62efd623
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14.1 MB | Download |
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md5:76063dda8c78aca489e6187e48251fb8
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531.4 kB | Download |
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md5:9b2ddae4bc6a737e484a5e12962c3c4f
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14 Bytes | Download |
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md5:b1a3dad39963a8a19f80f8c48e9c6d15
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19 Bytes | Download |
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md5:3b9100f143739b81506ebb62fb007419
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2.0 kB | Download |
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md5:ec4267b9e5d233ff74f11c9712ffe207
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25.2 MB | Download |
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md5:eed5c4b57c48a1c7f17e80d5c5e9a06b
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902.7 kB | Download |
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md5:6ebac9b476e75694be17b280e89fe6b3
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18 Bytes | Download |
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md5:00d42139014ec41140ffa7e434c7f82f
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19 Bytes | Download |
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md5:042c1dc0ffc690750675d5b1ec517f89
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2.1 kB | Download |
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md5:7f112899b70970641893c2f544fbd1c3
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16.8 MB | Download |
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md5:f843faf28cc7013f29cfdd70c194a809
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569.7 kB | Download |
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md5:a396e76f8a6879569c9b8960a106e2bc
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19 Bytes | Download |
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md5:199fffc998d0cd9f9e7a36e543e3a8ac
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13 Bytes | Download |
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md5:6b4f9861884fd766bcbff3edf6d713a0
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2.1 kB | Download |
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md5:f823649e6177bb386a339418408066b2
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16.3 MB | Download |
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md5:e771dea11c9cf4f8f8924307cb30d3ed
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556.3 kB | Download |
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md5:5cf5cabe6dd4a06b636a35b4eff297bb
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13 Bytes | Download |
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md5:eb155d4511f417460aa4f847827f1b3b
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19 Bytes | Download |
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md5:0cce12f3366fc7c28d216d3cc35abf72
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2.1 kB | Download |
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md5:72f2a6137fb32b77803330b55826e858
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15.9 MB | Download |
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md5:c862f18664b39a9872cba6b9756cf231
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526.0 kB | Download |
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md5:c84d8938a99c687c137f8b1152db6ba0
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19 Bytes | Download |
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md5:4b512be9881dba8a6733c4bbdaf055cf
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13 Bytes | Download |
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md5:422d569593c5cdc82d25b4f5c5720894
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2.1 kB | Download |
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md5:44b8206a18509a4fceead59dd7b8adb3
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12.0 MB | Download |
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md5:37c9ab16f1b3d1fd623fbefe90a1b162
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396.0 kB | Download |
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md5:a09f5a25c09c4422025ee30dfd491773
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13 Bytes | Download |
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md5:7bfae9c96680c3fcbc60374989352d88
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12 Bytes | Download |
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md5:beebfcd151e9dcd2513c9c39952cbe30
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2.1 kB | Download |
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md5:550322823e8e1b4820bcf91533fbfd08
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10.7 MB | Download |
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md5:cfa48ea821cb8d81e10cf69ee28fe68e
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360.6 kB | Download |
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md5:84bcd2d1f5d67e30b5d56c0901e7f835
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19 Bytes | Download |
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md5:d5b3448c493a7f864c6ef13416cb581b
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19 Bytes | Download |
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md5:493a93a5c8ccb82d5b24524015ac5aad
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2.1 kB | Download |
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md5:94c69703e7c3c4176f890812ced81364
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9.4 MB | Download |
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md5:970c79b15408aa6f415756956831a402
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330.6 kB | Download |
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md5:4d8bc037718123cecf9c2a0ff032fd8b
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13 Bytes | Download |
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md5:73b2326553214d7d2af8654b39922772
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13 Bytes | Download |
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md5:ef3ee2a43997e713a8481f2edd78c046
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2.1 kB | Download |
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md5:74929a74376d988888b0f8bfdaad054a
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10.3 MB | Download |
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md5:a64e6984b18010e94aa82c41958ace7c
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324.3 kB | Download |
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md5:7f304d3fafbb4cd2bec5a22cadee4d4f
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19 Bytes | Download |
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md5:570c189478085bcbd7876e45e048afe5
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19 Bytes | Download |
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md5:500c8f05d52b622c6da019d2ff65ba7f
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2.1 kB | Download |
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md5:cfffb0a92f7d37c61beddada04f02865
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8.8 MB | Download |
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md5:a9647f417a59ece4feaf09412adcf3ca
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300.8 kB | Download |
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md5:f529a10baafc407bf92c30f9b973b43c
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19 Bytes | Download |
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md5:d95784e410b8f87ce16d714c33f0a455
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19 Bytes | Download |
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md5:a9f535e2d68bf7301d738df73783591a
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2.1 kB | Download |
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md5:1aab9e902c3e21f77fc564c6a01f6431
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9.3 MB | Download |
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md5:3c83231516580e797d642787516a6e17
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315.2 kB | Download |
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md5:a7f176216b7ef03901ff52bc43bc2d6f
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18 Bytes | Download |
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md5:6477607c776442212a9b9b5c33628bbc
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18 Bytes | Download |
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md5:4d78a4b0537680e108f0320abb97e9fe
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2.1 kB | Download |
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md5:34090b508a0ffb0a353ec70c557175da
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7.6 MB | Download |
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md5:35fbd64363beaf6289808d5a44ffcbac
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211.5 kB | Download |
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md5:38893cd377f3108051a198f58ff8449a
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18 Bytes | Download |
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md5:064ac593b341c033d6aec5584435bb8e
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13 Bytes | Download |
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md5:b411248d11a983fb2193bb031613255c
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2.1 kB | Download |
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md5:ba05da075ccc6ed7dc08b4167d06d148
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27.2 MB | Download |
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md5:9f6bf69ad0a67872f915e55e0248468c
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912.2 kB | Download |
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md5:df06f8321d7c29e5d72ebb6300ba02a4
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19 Bytes | Download |
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md5:9dc7033763ad20374110a1039d3fa2d5
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13 Bytes | Download |
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md5:af0c06e74c7e202d2d9bc462406e1392
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2.1 kB | Download |
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md5:994fe179ca540ad7616a70033b438b18
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7.2 MB | Download |
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md5:948a6300b62b49349895b60304995a29
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271.5 kB | Download |
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md5:db5cd6405d944b489f762542d425bde9
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12 Bytes | Download |
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md5:6224f307e10247a1b4e1e8ee0a8bcc73
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19 Bytes | Download |
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md5:7ce268c88a4bd7293fe944ef958d6f0d
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2.2 kB | Download |
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md5:160ebdf181eca3992a7dc0261dfda961
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4.5 MB | Download |
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md5:07c852822305227040d63ccb0600d23a
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141.3 kB | Download |
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md5:a8eba1c0ae84e0b99363a8b4adb4247c
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12 Bytes | Download |
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md5:81dcecae9e435369317797fc6e85e7ac
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12 Bytes | Download |
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md5:6142f4ffb43ea285d19ef0e674dd3dc7
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2.1 kB | Download |
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md5:ae66489e56b129d5da90d525b7840ea5
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4.6 MB | Download |
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md5:c10556ee80227ea063227ed875a774ec
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152.7 kB | Download |
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md5:6d6ba4833b1a6f50ecb42e9491356fee
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11 Bytes | Download |
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md5:24b15a6f109ef95a3ee49dcbc9647700
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11 Bytes | Download |
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md5:d265fa628a171d7fee5b866f7e41cfba
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2.1 kB | Download |
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md5:8a749a8604d49906ff854326e2ae2230
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22.7 MB | Download |
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md5:57d15ba689d22623e40e938606a969e8
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758.6 kB | Download |
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md5:265ce8b3e383e27c05042ab5d2136430
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13 Bytes | Download |
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md5:9882232412899472f1f6856779f56b14
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13 Bytes | Download |
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md5:bd605b2bb7318d015359263a643661dc
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2.1 kB | Download |
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md5:c9b29e6352c0a49d795853527691f628
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23.5 MB | Download |
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md5:0952b75b88bf8ec63f2456f38ca559d6
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668.9 kB | Download |
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md5:a81eafc05d7a9d8a0f30dd5df40cfc35
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19 Bytes | Download |
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md5:2ec32d1dd55af99c4ff710149bafddca
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19 Bytes | Download |
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md5:617c753841f9397b437b8487b92ade7c
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2.1 kB | Download |
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md5:a39433f95b00d3141bc1316d3e5ae2f8
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20.3 MB | Download |
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md5:56892d2030aab33ca11aa1705570a8fc
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679.3 kB | Download |
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md5:2faf63144cfaef86e0a468c0e1caa7d6
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19 Bytes | Download |
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md5:3a0547b7e2c92997ff7d91968c919c8d
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19 Bytes | Download |
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md5:7c83ae8be6b46f51050fa5657d91524f
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2.1 kB | Download |
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md5:db7b0859f4ad69dc6f9d18e469527b5e
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21.2 MB | Download |
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md5:411ab8f35d8fbf22b7fcc8d0c5605179
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668.4 kB | Download |
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md5:c36ab150ae16fcafd7d481dde527e707
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19 Bytes | Download |
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md5:3d8546b281756b26253509e137a0cbba
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18 Bytes | Download |
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md5:7a5189ef5e9250e1fbad6fa8393eb868
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2.1 kB | Download |
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md5:e028f7a12530e0718a5cca831d37516a
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18.9 MB | Download |
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md5:3b6b4c76a085396c79d9f5f9f8646877
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601.5 kB | Download |
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md5:ccaeecb89645efa36721f46680a45b47
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18 Bytes | Download |
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md5:fadf3f15d625f480286c6f7f8867435e
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13 Bytes | Download |
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md5:301f245d0d5253cb0ef42e0d773878c4
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2.1 kB | Download |
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md5:9608750bf9e4f6288a57d563221da977
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17.6 MB | Download |
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md5:de02ce3d6966af330dab4f73b6fa6b16
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574.4 kB | Download |
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md5:cc9af548852508f720c8cc108f76d940
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13 Bytes | Download |
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md5:2089a674afcce22da27fc2730b5f1155
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19 Bytes | Download |
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md5:64ff95236972268dff2f52207da85e5c
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2.1 kB | Download |
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md5:8aa4629cee251dcb8e16793be59efaa1
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14.0 MB | Download |
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md5:054972163e5c8317622d80bcd5d6ab59
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490.1 kB | Download |
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md5:7204d9e54384b60719950053b3dd8319
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13 Bytes | Download |
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md5:117ed551d732d2f26d4f006ccf4c4a98
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19 Bytes | Download |
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md5:afb63695fc91dd4ceffbe7d2a77e91f4
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2.1 kB | Download |
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md5:6bf161b45f7f2c4e23f781afe6199abd
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25.4 MB | Download |
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md5:c5c1f0415e11a46888d69585939bc5b0
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953.3 kB | Download |
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md5:8c42bbf10f015b0c53c348a2647683d9
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19 Bytes | Download |
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md5:f0eb3613c6030f76de9b6b048fe9ace4
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19 Bytes | Download |
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md5:71769c84a47bb63f1789c2ccb0cd96c4
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2.1 kB | Download |
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md5:4dbe1127755b8cb0604f5964f45834ff
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17.0 MB | Download |
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md5:cc7a4cbd4401575e9e51a51c589a80dd
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600.3 kB | Download |
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md5:d85c1fea0eebe35e501a0fa2d77101f8
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14 Bytes | Download |
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md5:9877c42fbd8e948e3d7dc60405147bbc
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18 Bytes | Download |
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md5:365b8a00cd9616efa50d9f90dd2263c3
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2.1 kB | Download |
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md5:fab88f7196f311c74dd01d5f50e98279
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16.4 MB | Download |
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md5:eaa6285c142bdedc57a9aa5b776d9733
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582.9 kB | Download |
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md5:83867153322416dda6031cd51f20862e
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18 Bytes | Download |
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md5:8a4c16c98c65afab1817436b62528d47
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13 Bytes | Download |
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md5:a3f913c90ecf60e6dae8a1f8acac082e
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2.1 kB | Download |
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md5:d167c0e7b6dbc6e1efea1b124806623f
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16.0 MB | Download |
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md5:bb45ef0c3215dba31e66c5c4c491ab05
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557.2 kB | Download |
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md5:68d6b650f7e272fd5285106b43e459ba
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14 Bytes | Download |
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md5:1fa041485c49b14213f7231d409c7d20
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18 Bytes | Download |
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md5:60916734961dc9a3ecabac88742f266c
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2.1 kB | Download |
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md5:b8a9b64086fe6117eee2de9727e0eede
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12.1 MB | Download |
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md5:556e8ad326221096fc10433651cf651f
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420.0 kB | Download |
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md5:7bd12765b0a566614bc3192ae2d84a75
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14 Bytes | Download |
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md5:877b955739b16dfc9346f3c6c8b03431
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14 Bytes | Download |
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md5:433905ed21b57ffc7b994f41aa8bd511
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2.1 kB | Download |
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md5:ba0eab870fd04a1b956815c28951ced1
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10.8 MB | Download |
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md5:a862a2d6c82b44b2c03626554503b2f4
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377.6 kB | Download |
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md5:6bbbcc26d910b3c03ef5369a3cc96b04
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14 Bytes | Download |
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md5:0497acb040c6e303f22e185cf7b6ca4c
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19 Bytes | Download |
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md5:c6e949c215354f5fff51fda562d2ce8f
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2.1 kB | Download |
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md5:6eb25314922cca384970d9f2530ece80
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9.5 MB | Download |
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md5:a951309b7ad94e56d1e427f79d203dfe
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342.4 kB | Download |
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md5:d26a5e24a47ff0c24c7bdcb020f20598
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13 Bytes | Download |
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md5:03775776db6342fe5400116548454dbd
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13 Bytes | Download |
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md5:9584ca2aa96f460ed5af79d97baaa5d1
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2.1 kB | Download |
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md5:8e3fdd2c9041f09fd0380704424f79c1
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10.4 MB | Download |
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md5:6e947baf7be6b604ea9286473f6df01d
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344.8 kB | Download |
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md5:eb68beb381b82f2db6543fdbbbcd6e67
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13 Bytes | Download |
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md5:c236df5640c42cb524ec35bfd85f4b59
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19 Bytes | Download |
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md5:776e74d2db620fe7f7bf50fb441d1ac0
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2.1 kB | Download |
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md5:356e515803111c2bb6ca664b7ffb2ff5
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8.9 MB | Download |
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md5:20f837843fa0079c284e1f1fd59cf7fd
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313.8 kB | Download |
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md5:e287cc854754b13d8a39b820926a244c
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18 Bytes | Download |
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md5:1ae730a7db5a8d7bfa42acc540b9ce45
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18 Bytes | Download |
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md5:74db2783782d25b935b941330434ce9a
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2.1 kB | Download |
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md5:1f35d64f5174fee4724e5cd7b249d308
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9.4 MB | Download |
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md5:45223fddad87a3978123b99c08d5118a
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335.1 kB | Download |
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md5:749cb49596e2fe821fda7ac0711ca41c
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19 Bytes | Download |
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md5:0b9180de41038f56690b5528c28851ab
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14 Bytes | Download |
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md5:326d90901cc124e1d745fe23650b0cf2
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2.1 kB | Download |
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md5:0378b5e648e6e3df625e7950df5f9343
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7.7 MB | Download |
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md5:953ee602cd15a5286999a7427c605f9b
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219.8 kB | Download |
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md5:390f384a08610258185e9fd0fa359aa0
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13 Bytes | Download |
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md5:62376e0a5f15f5e4ed6b4ba1ec0bef0f
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12 Bytes | Download |
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md5:39a3e0a6d86ae1fee14bf9e1856ed96d
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2.1 kB | Download |
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md5:b13108a237d7fbb6f44990ac8f26f171
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27.4 MB | Download |
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md5:4d30b6a6a5ff0e4727663c8c54e39377
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961.6 kB | Download |
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md5:c94e8a16371dd32c1e9a77ae1841b412
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18 Bytes | Download |
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md5:c2a7b1ed1cd8e334ea6b027217cd3b63
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18 Bytes | Download |
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md5:9ace8311cbd7f269f376d4b3a8520411
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2.1 kB | Download |
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md5:83cab54e3236c62cea1511755ef325c5
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7.2 MB | Download |
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md5:11c3ecc5ef32549b8236d8d6ee92d12e
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285.3 kB | Download |
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md5:4d6d8af64e883143e14275a30ca48042
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19 Bytes | Download |
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md5:0992efa6528926c1db9a88f8ea41cc7f
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18 Bytes | Download |
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md5:6d015ae371ab15bbf8bbe23e5d261d61
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2.1 kB | Download |
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md5:6923a19c4d15e2090276e10831a7d7ed
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4.6 MB | Download |
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md5:f576478221e457316fbd979c4f62ca6b
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152.0 kB | Download |
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md5:b3611a51fdedaca92d642f6a701b169a
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19 Bytes | Download |
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md5:9d7612fc2af35245de32484f180ae734
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13 Bytes | Download |
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md5:49895d599d518c52fedd91de8ae4f5a4
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2.1 kB | Download |
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md5:b2eedb3c5975c07d91fb6af7f889cee9
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4.7 MB | Download |
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md5:24648774ccd3953f8088ce060681f770
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163.8 kB | Download |
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md5:8a200819a8a540da074dc6efa30a424b
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13 Bytes | Download |
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md5:32a35f3350b117243ee11a1a01bbb4fd
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13 Bytes | Download |
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md5:c1a3c30895e1aba0ad674f49046567f3
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2.1 kB | Download |
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md5:c596d4e0651900150fbf6441b4e419a6
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22.9 MB | Download |
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md5:8c20b4f13665879312671f8f63cda962
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797.9 kB | Download |
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md5:ebcd76a87bd1818c06be1f22cad2ec71
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18 Bytes | Download |
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md5:4eb3c866ac1318012fa261a67566695f
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18 Bytes | Download |
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md5:887abe08598acdda9c0d7cde230149fa
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2.1 kB | Download |
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md5:3b3601dae7ab829419eb002d5f9e0898
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23.6 MB | Download |
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md5:5a30e50ad1dc725522f33d11ac686776
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714.1 kB | Download |
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md5:1f4c3dda978485ccbec387465ad2f748
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18 Bytes | Download |
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md5:d319af69869e75abdd54da4b87764964
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14 Bytes | Download |
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md5:53d7dbaef812f0286afb3e0dc377fbef
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2.1 kB | Download |
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md5:91261efb771d52027c1de56603a2b6dc
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20.5 MB | Download |
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md5:12e555c8a71230c1f2d890ce0d420ae9
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717.0 kB | Download |
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md5:96af0030ecd2815ea00854b7357102cb
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18 Bytes | Download |
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md5:22759fdbb81f85dfe5e79ed0032aeabf
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18 Bytes | Download |
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md5:ae105f99517248b245f3308eac5fbdbb
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2.1 kB | Download |
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md5:f423429e2989b6e1b1b06f55a5775c9a
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21.3 MB | Download |
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md5:0f797f7b52894ce30749f167d4b04485
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709.8 kB | Download |
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md5:6a83b7d82ee08f5e1e006652d84c27a7
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18 Bytes | Download |
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md5:8b823cdfc74bac406efa41fcba85423a
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18 Bytes | Download |
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md5:9c7caad90178c21714c9025d2e3a4045
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2.1 kB | Download |
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md5:f1a556735edaf53bd1cb1b2899d55e24
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19.0 MB | Download |
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md5:73610f6eab631d3e1ed2937b974f9485
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631.9 kB | Download |
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md5:44d1ee0534eaf652262b3bda73834677
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18 Bytes | Download |
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md5:64f2edda660f53e18ce2525dc065626b
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18 Bytes | Download |
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md5:3daa282711acbeaf482552f8146f5190
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2.1 kB | Download |
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md5:92affcae8bd852afe4bbc99828b3944d
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17.7 MB | Download |
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md5:b46f526ebf7f5bffaab22f7ca907abee
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613.8 kB | Download |
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md5:329cdd0094fd546934c8f8360e94227c
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18 Bytes | Download |
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md5:c7ebfb62be105ee2f5f854996d86bcd9
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18 Bytes | Download |
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md5:8d20fcb4f233976bb88902c37b68b4e0
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2.1 kB | Download |
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md5:9661c08d85e3251a4cfe80c8d32a6c96
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14.2 MB | Download |
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md5:831c1c5cffaf1eed0699df5aed28fe51
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518.8 kB | Download |
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md5:222e82c5670e518a6f9979f8abf8b694
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14 Bytes | Download |
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md5:4b0746b9c50d7926a588d36f61ac0b10
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14 Bytes | Download |
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md5:0cc80c4da2e847488438c0a4be3ac1b8
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2.1 kB | Download |