Assessment of the anti-hyperglyceamic effect of Ficus asperifolia plant leaf aquous extract on alloxan-induced diabetic rats

ABSTRACT

This study is aimed at assessing the effects of Ficus asperifolia plant leaf extract on diabetic-induced albino rats. Diabetic animals were treated with various extract doses of F. asperifolia leaves for 24 days. The diabetic rats showed a decreased level of blood glucose when compared to rats not treated. There was a significant (p<0.05) decrease in serum triglyceride, cholesterol and LDL but a remarkable increase in HDL values of the treated rats compared to the controls administered with distilled water. Haematological analysis also showed that there was a significant increase in PCV, RBC, and Hb values of the treated rats compared to the normal. These results suggested that oral administration of F. asperifolia possess significant anti-diabetic potentials. With this finding it can be concluded that the anti-diabetic effect of F. asperifolia may be due to its bioactive compounds responsible for anti-diabetic activity present in the leaf extract.

Key words: Diabetes mellitus, induction, Ficus asperifolia, allozan monohdrate, haemetotology,  glucose,

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