Changes in testicular DNA in mice against immunostimulation and hepatitis

ABSTRACT

Male swiss albino mice were treated with immunostimulant (@ 150 mg/mouse) (group I), and immunostimulant (@ 150 mg/mouse) + antigen (@ 0.007 ml to 1 ml) (groups A to F).   One group (N) of mice was kept as controls (untreated) for comparison.  Estimation of testicular DNA was done on day 1,2,3,4 and 5 (on day 11 to 15 of experimental design) of experimental period after immunostimulation and/or antigenation.  Mice treated with immunostimulant alone showed significant increase of testicular DNA when compared with controls.  However, experimental mice (treated with immunostimulant + antigen, groups A to F) recorded marked alterations (increase or decrease) in the level of DNA when compared with controls and immunostimulated mice.  Treatment of mice (experimental) with immunostimulation and antigen resulted in various temporal changes in the DNA content in testes.

Keywords: Immunex DS,Hbs Ag, DNA,Mice.

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