Plasma beta2 microglobulin as a marker of progression in chronic Kidney disease patients

ABSTRACT

Chronic kidney disease (CKD) is a world-wide public health problem with adverse outcomes of kidney failure. Early diagnosis and treatment may delay or even prevent the onset of nephropathy in CKD. The measurement of glomerular filtration rate (GFR) is the gold standard for the assessment of renal function.  Beta 2 microglobulin has a renal handling compatible with that of an “ideal” marker of GFR. In fact, they are cleared by the plasma through free glomerular filtration, subsequent complete tubular resorption, and degradation inside tubular cells. As a consequence, their serum concentrations increase progressively with the reduction of GFR. The current study was designed to determine the values of this biomarker in patients with different levels of renal dysfunctions and find out the correlation between serum B2 Microglobulin, serum creatinine, blood urea nitrogen and glomerular filtration rate in patients with different levels of renal dysfunction.  In this study we found that the levels of serum B2 Microglobulin are highly associated with renal impairment in CKD stages, its concentrations significantly increased from stage 1 to 5 and that these levels progressively increase with decreasing GFR.\

Keywords: B2 Microglobulin, Serum creatinine, Creatinine clearance, Renal function.

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