SYNTHESIS OF PHARMACEUTICAL IMPORTANT OF ZN(II)COMPLEX FROM ANTIDEPRESSANT RESIDUES OF 4-OXOPIPERIDINE HYDRAZONE: ANTIBACTERIAL, ANTIFUNGAL, AND UV-VISIBLE STUDIES

The [Zn(L)(H₂O)₂Cl] complex was synthesised from with salt of Zn(II)Cl₂.6H₂O and 2-hydroxynaphthalen-1-yl) methylene-4-oxopiperidine-1-carbohydrazide Schiff base (H₂L). The newly synthesized Schiff base and its Zn(II) complex was screened against the various pathogenic species viz. Escherichia coli, Salmonella typhi, Staphylococcus aureus, Bacillus subtillis, Candida albicans, and Aspergillus niger with the popular antibiotics of ofloxacin, azithromycin, and fluconazole. On the basis of inhibition zone data of Zn(II) metal complex was  enhancing the potential activities and may be a good antimicrobial candidate in the biological science.

Additionally, The Zn(II)complex was characterized by molar conductivity, magnetic moment. The Schiff base ligand shows a dibasic in nature, ONO tridentate moiety and bonding occurred by the phenolic-O, azomethine-N (H-C=N-) and enolic-O atoms with the Zn(II) complex.

Keywords: Schiff base, Zn(II)complex, X-ray diffraction, antibacterial and antifungal activities.