NOVEL COUMARIN DERIVATIVES: SYNTHESIS, CHARACTERIZATION AND ITS BIOLOGICAL VALUATIONS

Compounds containing coumarin backbone are unit an awfully necessary cluster of compounds as a result of their usage in pharmacy and drugs. Properties and biological activities of coumarin derivatives have a giant role inside the event of recent drugs. Therefore, many alternative ways and techniques area unit developed thus on synthesize coumarin derivatives. Coumarin derivatives could also be obtained from whole totally different starting materials with varied ways but with vast variations in yield. Coumarins possesses different kinds of biological activities like medicine, antimicrobial medication, analgesic, inhibitor, anticancer, antiviral etc. Coumarin belongs to a bunch as Benzopyrones that consists of a benzene nucleus joined to a pyrone nucleus. These freshly designed Coumarin derivatives were screened for medication activity by gum induced rat paw hydrops model, medication and antifungal activity. Coumarin is of the benzopyrone thus, it is the essential particle which can be synthesis from them additional sophisticated for the Coumarin derivatives that containing alkyl groups or radical or unit as imitative totals. In vitro toxicity studies and in vivo acute oral toxicity examination additionally counsel that the synthesized compounds are unit non-toxic in nature. Coumarin and their derivatives have attracted vital attention within the scientific world due to their unbounded applications in knowledge domain areas. This work incontestable a simple and economical approach to developing coumarin derivatives as outstanding compounds.

Key words: - Coumarin, Benzopyrones, Analgesic, Antifungal, Anticancer activity etc.