EVALUATION OF ANTICONVULSANT ACTIVITY OF APIUM GRAVEOLENS ON DIFFERENT INDUCING MODELS IN MICE

Epilepsy is a chronic CNS disorder characterized by brief episodesof seizures and excessive EEG discharge. The selection of this plant, Apium graveolens was made on the basis of its High therapeutic value, Easy availability, Degree of research work which is not done. Apium graveolens contained appreciable amount of tannins, flavonoids, steroids, saponins, however, terpenoids content was almost negligible. The Ethanol extract of Apium graveolens delayed the onset and reduced the duration of convulsion in MES and PTZ induced convulsion models and can be used as an adjuvant therapy against cognitive deficit in convulsions. The extract also shows significant decrease in lipid peroxidation level and increase in reduced glutathione level, indicates that EAG possess good antioxidant activity. Also, EAG significantly increased the level of inhibitory neurotransmitter GABA and also showed increase in DA, NA and 5-HT levels. Hence it can be concluded that the EAG possesses good anticonvulsant activity. Further studies are needed to explore the mechanism as well as the active principle responsible for the anticonvulsant activity of Apium graveolens.

Key words: Anticonvulsant activity, Apium Graveolens, Mice.