Self Emulsifying Drug Delivery System

Self-emulsifying drug delivery systems (SEEDS) are mixtures of perfect isotropic oils and surfactants, with or without cosolvents, that emulsify when gently agitated, similar to the conditions found in the gastrointestinal tract. These systems cause the gastro-intestinal tract (GIT) to mildly agitate while forming fine emulsions (or micro-emulsions). The oral absorption of drugs from SEEDS is greatly influenced by a number of factors, including surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size, and charge. This formulation improves bioavailability by increasing drug solubility and reducing gastric irritation.Gelatin capsules in either soft or firm form may be used orally. More than 40% of novel chemical entities, however, have low aqueous solubility, which leads to ineffective oral medication administration. Selfemulsifying drug delivery systems (SEEDS), which increase the oral bioavailability of poorly water soluble medicines, have received a lot of interest latel