Published November 9, 2022
| Version v1
Journal article
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Sequencing, Mutation and Evolution of SMC Proteins: An Overview
Authors/Creators
- 1. 1*Department of Veterinary Pathology, Kamdhenu University, Junagadh 1Department of Veterinary Physiology and Biochemistry, Kamdhenu University, Navsari
Description
- SMC stands for Structural Maintenance of Chromosomes, these proteins represent a large family of ATPases that participate in various aspects of higher-order chromosome organization and dynamics (Losada & Hirano, 2005).
- In 1993, the first SMC protein was characterized as a gene product required for proper chromosome segregation in yeast. Same year, using different approaches, a number of related proteins were identified in different organisms, laying the foundation of the SMC superfamily.
- These proteins are large polypeptides, each spanning 1000–1500 amino acids. They form dimers in which two antiparallel coiled-coil arms are connected by a flexible hinge and the distal end of each arm constitutes an ATP-binding domain.