EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTIULCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CASSIA AURICULATA

Ulcer is the most common gastrointestinal disturbance resulting from an inadequate gastric mucosal defense. Several drugs are available in the market to address the disease; however, these drugs are associated with unnecessary side effects. Previous research has confirmed the efficacy of plant extracts for possible treatment of the disease. This research aims to evaluate the anti-ulcer properties of medicinal plants Cassia auriculata. The present study is aimed to evaluate the antiulcer activity of hydroalcoholic extract of Cassia auriculata plant in rats. The antiulcer activity of the Cassia auriculata plant extract was evaluated in pyloric ligation model and ethanol induced gastric ulcer model. In pyloric ligation model, the rats were divided into four groups of six each.  Group I rats were treated with vehicle and served as negative control and Group II rats were treated with standard drug Ranitidine 50 mg/kg , Group III and IV treated with hydro alcoholic extract of Cassia auriculata (200 and 400 mg/kg, p.o respectively. The hydroalcoholic extract at the dose of 200 and 400 mg/kg showed 30.57 and 62.76 % protection respectively against pyloric ligation-induced ulcer. In conclusion, the hydroalcoholic extract of I. Cassia auriculata has antiulcer activity.

Key words: Cassia auriculata, Hydroalcoholic extract, Antiulcer activity