Published November 1, 2022 | Version v1

Phytochemical and Pharmacological profile of Citrullus lanatus (THUNB)

  • 1. Centre for Research and Development, Pacific University, Udaipur, Rajasthan, India,
  • 2. B. R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India,
  • 3. Department of Pharmacology, MAEER'S Maharashtra Institute of Pharmacy, Kothrud, Pune, India.

Description

ABSTRACT

Citrullus lanatus Thunb (Family: Cucurbitaceae) is a medicinal plant widely used traditionally in the treatment of various disorders in world. The phytochemical evaluation of plant showed presence of carbohydrate, alkaloids, steroids, saponins, glycoside, flavonoids, tannins and phenolic compounds. The plant also showed presence of vitamins, amino acids, proteins, minerals and fat. The plant has been extensively studied by various scientist and researchers for its pharmacological activities and therapeutic approaches such as antibacterial, antifungal, antimicrobial, antiulcer, antioxidant, anti-inflammatory, gastroprotective, analgesic, laxative, antigiardial, hepatoprotective, against prostetic hyperplasia and atherosclerosis. The present review is an effort to provide detailed information of its uses, chemical composition, pharmacological activities of extract and its isolated compounds and safety profile of Citrullus lanatus for further research.

Keywords: Citrullus lanatus, Cucurbitaceae, Citrulline, Giardiasis.

REFERENCES

  1. Mabberley DI, 1987. The Plant Book. Cambridge: Cambridge Univ. Press, New York.
  2. Gill NS, Kaur S, Arora R,  Screening of antioxidant and anti-ulcer potential of citrullus lanatus methanolic seed extract, Research J of Phytochem 2011; 5 (2): 98-106.
  3. Mercy GA, Bosa EO, The morphological characterization of the melon species in the family cucurbitaceae juss., and their utilization in Nigeria, International J of Modern Botany 2013; 3(2): 15-19.
  4. Jain S, Jerald EE, Edwin S, Isolation, fractionation and evaluation of the anti-inflammatory properties of Citrullus lanatus Thunb, Asian J of Biomed & Pharma Sciences, 2013; 3(20):66-72.
  5. Varghese S, Narmadha R, Gomathi D, Phytochemical screening and HPTLC fingerprinting analysis of Citrullus lanatus (Thunb.) seed, J of acute Disease 2013:122-126.
  6. Ahmed Hassan LE, Sirat HM, Yagi SM, In vitro antimicrobial activities of chloroformic, hexane and ethanolic extracts of citrullus lanatus var. Citroides (wild melon), J of Med Plants Res 2011; 5(8): 1338-1344.
  7. Thirunavukkarasu P, Ramanathan T, Screening of antimicrobial effects in watermelaon, J of Biol Sci 2010:1-4.
  8. Olamide AA, Olayemi OO, Demetrius OO, Effects of methanolic extract of Citrullus lanatus seed on experimentally induced prostatic hyperplasia, Eur J of Med Pla 2011; 1(4): 171-179.
  9. Braide W, Odiong IJ, Oranusi S, Phytochemical and antibacterial properties of the seed of watermelon (Citrullus Lanatus), Prime J  of Micro  Res 2012; 2(3): 99-104.
  10. Thirunavukkarasu P, Ramanathan T, Screening of antimicrobial effects in watermelaon, J of Biol Sci 2010: 1-4.
  11. Sathya J, Shoba FG, Assessment of antimicrobial efficacy of Citrullus lanatus methanolic seed extract, J. Chem. Pharm. Res 2014; 6(12):640-643.
  12. Gill NS , Sood S, Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats, Lat. Am. J. Pharm  2011; 30 (3): 429-434.
  13. Lucky OO, John UO, Quantitative determination, metal analysis and antiulcer evaluation of methanol seeds extract of Citrullus Lanatus thunb (Cucurbitaceae) in Rats, Asian Pac J of Trop Dis 2012; S1261-S1265.
  14. Bhardwaj A, Kumar R, Dabasa V, Evaluation of anti-ulcer activity of Citrullus lanatus seed extract in wistar albino rats, Int J Pharm Pharm Sci; 4 (5):135-139.
  15. Rahman H, Manjula K, Anoosha  T, In-vitro anti-oxidant activity of Citrullus lanatus seed extracts, Asian J Pharm Clin Res 2013; 6 (3):152-157.
  16. Madhavi P, Maruthi R, Kamala V, Evaluation of anti-inflammatory activity of citrullus lanatus seed oil by in-vivo and in-vitro models, Int. Res J Pharm. App Sci 2012; 2(4):104-108.
  17. Deng JG, Wang S, Anti-inflammatory and analgesic effects of extract from roots and leaves of citrullus lanatus, Chine Herb Med, 2010; 2(3): 231-235.
  18. Sharma S, Jain S, Dwivedi J, Gastroprotective activity of Citrullus lanatus in rats, A Paci J of Trop Biomed 2012: 1-6.
  19. Sharma S, Paliwal S, Dwivedi J, First report on laxative activity of Citrullus lanatus, Pharmacologyonline 2011; 2: 790-797.
  20. Hassan LE, Koko WS, In vitro antigiardial activity of citrullus lanatus var.citroides extracts and cucurbitacins isolated compounds, J of Med Pla Res 2011; 5(15): 3338-3346.
  21. Altas S, Kizil G, Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats, Food and Chem Toxicol  2011; 49: 2433–2438.
  22. Poduri A, Rateri DL, Citrullus lanatus ‘sentinel’ (watermelon) extract reduces atherosclerosis in LDL receptor-deficient mice, J of Nutri Biochem 2013; 24: 882–886.
  23. Oluwole FS, Balogun ME Antisecretory effects of watermelon (citrullus lanatus) juice in male albino rats, Ann Revi & Res in Biol  2013;3(4): 358-366.
  24. Kumari A, Rao J, Kumari J, Analgesic activity of aqueous extract of Citrullus Lanatus peels, Adv in Pharmacol and Pharma 2013;1(3): 135-138.
  25. Varghese S, Narmadha R, Evaluation of hypoglycemic effect of ethanolic seed extracts of Citrullus lanatus, J of Phytopharmacol 2013; 2(6): 31-40.

Files

33.18n.pdf

Files (1.1 MB)

Name Size
md5:662d391aeafa0ed96fe2264c09c49c86
1.1 MB Preview Download