The protective effect of zinc and its relationship with some hematological, biochemical, and histological parameters in adult male rats
Authors/Creators
- 1. Department of Medical Laboratory, College of Health and Medical Techniques-Kirkuk, Northern Technical University, Iraq
- 2. Department of Medical Laboratory, College of Health and Medical Techniques- Kirkuk, Northern Technical University, Iraq
- 3. Department of Anatomy, College of Veterinary Medicine, University of Kirkuk, Iraq
- 4. Department of Community Health Techniques, Kirkuk Technical Institute, Northern Technical University, Iraq
- 5. Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Kirkuk, Kirkuk, Iraq
Description
The trace element zinc is essential for the construction and function of cellular proteins. The current study aimed to estimate the improved cause of zinc on the changes resulting from high concentrations of cholesterol. In this experiment, thirty male rats aged 3-4 months were randomly divided into three groups of ten rats each. Control group: the animals did not receive any treatment, cholesterol group: the animals received cholesterol at a concentration of 400 mg/kg mixed with diet for 4 weeks, while in the zinc group: rats received cholesterol at a concentration of 400 mg/kg for 4 weeks, then zinc was given 20 mg/kg for another 4 weeks. The study period was 56 days, after its completion, hematological and biochemical parameters were studied, in addition to the histological examination of the liver. The results showed that cholesterol treatment alone led to significant negative changes in hematological, biochemical and histological indices. Whereas zinc administration to experimental rats resulted in clear positive effects in those parameters. We concluded that the cholesterol-damaged rats improved after receiving zinc.