Aberrant change in brain network flexibility during the performance of Theory of Mind task in schizophrenia patients

A comparison of dynamic brain network reconfiguration captured by fMRI is performed between two groups of 64 schizophrenia patients and 64 healthy controls. The results show differences in three scales of single nodes, group of nodes, and whole network. These three scale measures are then used to train a generalized linear model (GLM) and predict the diagnosis based on the reconfiguration/flexibility of the brain during the Theory of Mind task. The results show a significantly higher than chance classification accuracy.