Salivary Metabolites in Mobile Phone Addicts with Sleep Disorders and Therapeutic Markers of Acupuncture Intervention

Mobile phone addiction (MPA) is a novel behavioral addiction causing diurnal rhythm disorders that severely affect mental and physical health. This work aims to detect rhythmic salivary metabolites in MPA with sleep disorder (MPASD) subjects and probe therapeutic markers for acupuncture intervention. The salivary samples of MPASD and healthy controls were collected at 4 h intervals for three days. Then, MPASD subjects received acupuncture intervention for 7 days, and circadian saliva samples were collected. LC-MS analyzed salivary metabolomes.