Sars-escape network for escape prediction of SARS-COV-2

This dataset belongs to a paper Sars-escape network for escape prediction of SARS-COV-2

Prem Singh Bist, Hilal Tayara, Kil To Chong

Briefings in Bioinformatics, Volume 24, Issue 3, May 2023, bbad140, https://doi.org/10.1093/bib/bbad140

Abstract

Motivation: Viruses have coevolved with their hosts for over millions of years and learned to escape the host's immune system. Although not all genetic changes in viruses are deleterious, some significant mutations lead to the escape of neutralizing antibodies and weaken the immune system, which increases infectivity and transmissibility, thereby impeding the development of antiviral drugs or vaccines. Accurate and reliable identification of viral escape mutational sequences could be a good indicator for therapeutic design. We developed a computational model that recognizes significant mutational sequences based on escape feature identification using natural language processing along with prior knowledge of experimentally validated escape mutants.

Results: Our machine learning-based computational approach can recognize the significant spike protein sequences of severe acute respiratory syndrome coronavirus 2 using sequence data alone. This modelling approach can be applied to other viruses, such as influenza, monkeypox and HIV using knowledge of escape mutants and relevant protein sequence datasets.

Availability: Complete source code and pre-trained models for escape prediction of severe acute respiratory syndrome coronavirus 2 protein sequences are available on Github at https://github.com/PremSinghBist/Sars-CoV-2-Escape-Model.git.  

Contact: premsing212@jbnu.ac.kr.

Keywords: SARS-CoV-2; mutation; sequence analysis; viral escape prediction.