KCC2 rs2297201 Gene Polymorphism Might be a Predictive Genetic Marker of Febrile Seizure

Introduction:Febrile seizures (FS) are the most common neurological disease in childhood. The etiology of FS is the subjectof numerous studies including studies regarding genetic predisposition.Aim:The aim of the study was to analyze the asso-ciation ofTRPV1rs222747 andKCC2rs2297201 gene polymorphisms with the occurrence of FS.Materials and Methods:The study included 112 patients diagnosed with FS classified as simple febrile seizures (SFS) or complex febrile seizures (CFS).We analyzed selected polymorphisms ofKCC2andTRPV1genes using the Real-time PCR method.Results:The CT and TTgenotypes of the rs2297201 polymorphism of theKCC2gene are significantly more common in the group of children with FSthan the control group (p=.002) as well as the allele Tof this polymorphism (p=.045). Additionally, genotypes CTand TTofthe rs2297201 polymorphism of theKCC2gene were more frequent in the group of children with CFS compared to the con-trol group (p< .001). Different genotypes and alleles of the rs222747TRPV1gene polymorphism were not associated with theoccurrence of febrile seizures or epilepsy, nor were associated with the occurrence of a particular type of febrile seizure (p=.252).Conclusion:These results indicate that the CTand TT genotypes, as well as the Tallele of rs2297201 polymorphism oftheKCC2gene, could be a predisposing factor for the FS, as well as the occurrence of CFS.