Published April 26, 2023
| Version 2.0.0
Dataset
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Single-molecule DNA methylation patterns of full-length human-specific LINE-1 (L1HS) retrotransposons in a panel of cell lines.
Description
We used bs-ATLAS-seq to comprehensively map the genomic location and assess the DNA methylation status of full-length human-specific LINE-1 elements (L1HS). The approach capture region 1-210 of L1HS elements, which corresponds to the most 5' end of its promoter sequence. This was performed in a panel of 12 human primary or transformed cell lines (BJ, IMR90, MRC5, H1, K562, HCT116, HeLa S3, HepG2, MCF7, HEK-293, HEK-293T, 2102Ep), many being shared with the encode project.
These datasets provide a visualization for DNA methylation patterns at the single molecule level for each L1HS loci.
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Additional details
Related works
- Is derived from
- Dataset: https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-10895 (URL)
Funding
- Agence Nationale de la Recherche
- RETROMET - Revealing the uniqueness of repetitive DNA: epigenetic regulation of L1 retrotransposons in human somatic cells at unprecedented resolution ANR-16-CE12-0020
- Agence Nationale de la Recherche
- UCA JEDI - Idex UCA JEDI ANR-15-IDEX-0001
- Agence Nationale de la Recherche
- SIGNALIFE - Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie ANR-11-LABX-0028
- Agence Nationale de la Recherche
- ImpacTE - The LINE-1 regulatory network: genome-wide impact of recent transposable elements on mammalian genic activity ANR-19-CE12-0032
References
- Lanciano S et al. Resolving the heterogeneity of L1 DNA methylation reveals the epigenetic and transcriptional interplay between L1s and their integration sites. bioRxiv 2023.01.03.522582; doi: https://doi.org/10.1101/2023.01.03.522582