Published September 17, 2022
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Marked improvement in a severe case of narcolepsy but not cataplexy on cortisol replacement therapy after decompensation of a primary non-Addison adrenal insufficiency
Authors/Creators
- 1. Jewish University (JUC)
- 2. LCG Greece
- 3. JUC Treatment Office Luxembourg
Description
After the short-term administration of max. 40/d prednisolone (orally) in a previously non-steroid-treated patient with iron storage disease, the steroid, which is omnipresent in clinical practice, led to paradoxical foudroyant symptoms, but above all to a reduction of >95% in the extreme narcoleptic symptomatology, not however in the cataplectic component. Masked primary adrenal insufficiency was revealed. An improvement in narcoleptic symptoms of about 25% was also maintained under oral hydrocortisone-only substitution therapy.
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Hydrocortison Narcolepsy - Observation report.pdf
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