Published September 16, 2022
| Version v1
Dataset
Open
Functional and metabolic alteration of gut microbiota in children with new-onset type 1 diabetes
Authors/Creators
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Yuan, Xiaoxiao1
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Wang, Ruirui2
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Ji, Guang2
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Luo, Feihong1
- Han, Bing1
- Sun, ChengJun1
- Chen, Ruimin3
- Wei, Haiyan4
- Chen, Linqi5
- Du, Hongwei6
- Li, Guimei7
- Yang, Yu8
- Chen, Xiaojuan9
- Cui, Lanwei10
- Xu, Zhenran1
- Fu, Junfen11
- Wu, Jin12
- Gu, Wei13
- Chen, Zhihong14
- Fang, Xin15
- Yang, Hongxiu16
- Su, Zhe17
- Wu, Jing1
- Li, Qiuyue1
- Zhang, Miaoying1
- Zhou, Yufeng1
- Zhang, Lei2
- 1. Fudan University
- 2. Shanghai University of Traditional Chinese Medicine
- 3. Fuzhou Children's Hospital of Fujian Medical University
- 4. Children's Hospital Affiliated to Zhengzhou University
- 5. Children's Hospital of Soochow University
- 6. The First Hospital of Jilin University
- 7. Shandong Provincial Hospital Affiliated to Shandong First Medical University
- 8. The Affiliated Children's hospital of Nanchang University
- 9. The Children's Hospital of Shanxi Province
- 10. The First Affiliated Hospital of Harbin Medical University
- 11. Children's Hospital, Zhejiang University School of Medicine
- 12. Sichuan University
- 13. Children's Hospital of Nanjing Medical University
- 14. Affiliated Hospital of Qingdao University
- 15. Fujian Medical University Union Hospital
- 16. Qingdao Women and Children's Hospital
- 17. Shenzhen Children's Hospital
Description
Worldwide T1D incidence has been steadily increasing annually over the past 30 years. The etiology of T1D is multifactorial, consisting of genetic susceptibility and environmental factors, including gut microbiota alterations. The comprehensive profiling of functional and metabolic dysbiosis of gut microbiota in T1D is lacking. To decipher the T1D-associated functional features of gut dysbiosis, we performed integrative metagenomic and metabolomic analyses in pediatric patients with new-onset T1D.